There are approximately 60 known females worldwide with this rare condition, although it is believed that there are probably many more who are undiagnosed.
More information about pentasomy X or 49,XXXXX:
Physical traits
XXXXX syndrome is associated with microcephaly (undersized skull), micrognathia (undersized jaw), and round face. The ears are generally low-set and malformed. Eyes are upslanting and show palpebral fissures, hypertelorism, and strabismus. Usually the nose is shaped with a broad and depressed nasal bridge and epicanthus, with the mouth having a cleft and highly arched palate, dental abnormalities, and thick, furrowed, and everted lips. The neck is webbed, much like the neck of a woman with Turner's syndrome.Growth and development
XXXXX syndrome causes mental, growth, and motor retardation. There is occasional delayed puberty. Recent observations have indicated an average of a 10 to 15 IQ point decrease for each extra X chromosome. Thus, the average IQ of XXXXX individuals tends to be between 55 and 70.Sources: http://www.genealogysource.com/tetra_x/information.htm
http://en.wikipedia.org/wiki/49,_XXXXX
Wow. How sad for these poor woman.
ReplyDeleteClarissa - I didn't know about this - thanks :-). I always learn from your blog.
ReplyDeleteIt's interesting that every x drops the IQ by 10.
ReplyDeleteI had no idea about this condition. Great post.
ReplyDeleteJai
Hadn't heard about this x syndrome before.
ReplyDeleteHow awful! :-(
ReplyDeleteI hope these poor women are ok and have good happy lives. Take care
x
That's awful!
ReplyDeleteNever knew anything like this existed. Interesting and sad all at the same time.
ReplyDeleteWow. I--like many other readers--have never heard of this. It's so sad to think of something like this existing.
ReplyDeleteI didn't know there was such a condition. Wow. It's interesting it affects the IQ.
ReplyDeleteRecent observations have indicated an average of a 10 to 15 IQ point decrease for each extra X chromosome
ReplyDeleteWhat does this say about the intelligence of the XY individual?
WOW! You certainly thought of something to write about - and you taught me something new! I had never heard of this condition before.
ReplyDeleteThis is very sad for those women. I didn't know about it. There is X-Syndrome, isn't there, where the tendency is to put on weight. Most of us seem to have this one!
ReplyDeleteDenise<3
Oh dear! It sound awful.
ReplyDeleteWow, very intersting!
ReplyDeleteI love your blog, quite busy trying to find all participating in the challenge.
ReplyDeleteSo glad I have only a couple xtra 'x's, I think they are in my head.
I'd heard of XXX, but never XXXX or XXXXX. I really amazes me how many things can go wrong in human development, and yet, how rarely it actually does.
ReplyDeleteI'd never heard of such a thing!
ReplyDelete